2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1901):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-131814
    5'-dGMPS
    5'-dGMPS is an analogue of 5'-dGMP and a potential substrate, competitive inhibitor or regulator of enzymes that interact with 5'-dGMP.
    5'-dGMPS
  • HY-154606
    2'-F-2'-ara-N2-ibu-dG Phosphoramidite
    2'-F-2'-ara-N2-ibu-dG Phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
    2'-F-2'-ara-N2-ibu-dG Phosphoramidite
  • HY-152612
    2’-Deoxy-2’-fluoro-5-hydroxymethyl arabinouridine
    2’-Deoxy-2’-fluoro-5-hydroxymethyl arabinouridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    2’-Deoxy-2’-fluoro-5-hydroxymethyl arabinouridine
  • HY-152778
    2-Chloro-3’-deoxy-3’-fluoroadenosine
    2-Chloro-3’-deoxy-3’-fluoroadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Chloro-3’-deoxy-3’-fluoroadenosine
  • HY-41793
    3'-O-(t-Butyldimethylsilyl)-2'-deoxy-2'-fluorouridine
    3'-O-(t-Butyldimethylsilyl)-2'-deoxy-2'-fluorouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3'-O-(t-Butyldimethylsilyl)-2'-deoxy-2'-fluorouridine
  • HY-W457757
    1,2-Di-O-isopropylidene-3-O-methyl-D-ribofuranose
    1,2-Di-O-isopropylidene-3-O-methyl-D-ribofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    1,2-Di-O-isopropylidene-3-O-methyl-D-ribofuranose
  • HY-154264
    5’-O-DMTr-N6-ethyl-2’-deoxyadenosine 3’-CED phosphoramidite
    5’-O-DMTr-N6-ethyl-2’-deoxyadenosine 3’-CED phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5’-O-DMTr-N6-ethyl-2’-deoxyadenosine 3’-CED phosphoramidite
  • HY-154477
    2-Amino-6-chloro-9-(3-deoxy-beta-D-ribofuanosyl)-9H-purine
    2-Amino-6-chloro-9-(3-deoxy-beta-D-ribofuanosyl)-9H-purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Amino-6-chloro-9-(3-deoxy-beta-D-ribofuanosyl)-9H-purine
  • HY-152529
    4’-C-Methyl-5-methoxyuridine
    4’-C-Methyl-5-methoxyuridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    4’-C-Methyl-5-methoxyuridine
  • HY-125818C
    Cytidine-5'-triphosphate disodium hydrate
    Cytidine 5′-triphosphate is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.
    Cytidine-5'-triphosphate disodium hydrate
  • HY-154305
    5′-Azido-2′,5′-dideoxy-2′-fluorouridine
    5′-Azido-2′,5′-dideoxy-2′-fluorouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 5′-Azido-2′,5′-dideoxy-2′-fluorouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    5′-Azido-2′,5′-dideoxy-2′-fluorouridine
  • HY-154137
    3’-Beta-C-Methyl-5-trifluoromethyluridine
    3’-Beta-C-Methyl-5-trifluoromethyluridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    3’-Beta-C-Methyl-5-trifluoromethyluridine
  • HY-W039271
    2-Chloro-6-methoxypurine riboside
    2-Chloro-6-methoxypurine riboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.
    2-Chloro-6-methoxypurine riboside
  • HY-152702
    2,8-Dimethyladenosine
    2,8-Dimethyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    2,8-Dimethyladenosine
  • HY-138596
    5'-O-TBDMS-dU
    5'-O-TBDMS-dU can be used in the synthesis of oligoribonucleotides.
    5'-O-TBDMS-dU
  • HY-152422
    3’-Beta-C-Methyl-N6-(m-trifluoromethylbenzyl)adenosine
    3’-Beta-C-Methyl-N6-(m-trifluoromethylbenzyl)adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    3’-Beta-C-Methyl-N6-(m-trifluoromethylbenzyl)adenosine
  • HY-152816
    2′-β-C-Methyl-2-methoxyadenosine
    2′-β-C-Methyl-2-methoxyadenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    2′-β-C-Methyl-2-methoxyadenosine
  • HY-154439
    3’-β-Amino-2’,3’-dideoxy-5’-O-trityl-5-methyl uridine
    3’-β-Amino-2’,3’-dideoxy-5’-O-trityl-5-methyl uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-β-Amino-2’,3’-dideoxy-5’-O-trityl-5-methyl uridine
  • HY-154469
    5’-O-DMTr-2’-O-MOE inosine 3’-P-methyl phosphonamidite
    5’-O-DMTr-2’-O-MOE inosine 3’-P-methyl phosphonamidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5’-O-DMTr-2’-O-MOE inosine 3’-P-methyl phosphonamidite
  • HY-155743A
    ddUTP (lithium), 100mM in H2O
    ddUTP (lithium), 100mM in H2O is a nucleotide analog that can be incorporated into DNA, RNA, or other nucleic acids. ddUTP (lithium), 100mM in H2O can be used to prepare DNA/RNA hybridization experiments, such as Southern blots and Northern blots.
    ddUTP (lithium), 100mM in H2O